![]() In our study, we found that deficiency of N元 led to morphological changes of the pyramidal neurons in layer II/III somatosensory cortex in mice, including enlarged somata, elongated dendritic length, and increased dendritic complexity. However, the detailed mechanism is still unclear. Studies in rodents have revealed that mutations of N元 gene lead to increased growth and complexity in dendrites in the central nervous system. Genetic defects in neuroligin 3 (N元), a member of the NL protein family, are associated with autism. Neuroligins (NLs) are a group of postsynaptic cell adhesion molecules that function in synaptogenesis and synaptic transmission. 9 State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong. ![]() 8 Division of Biomedical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.7 Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.6 JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, China.5 Department of Orthopaedics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.4 Zhejiang University-University of Edinburgh Institute, Jiaxing, China.3 Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.2 Department of Neurobiology, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, China. ![]()
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